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N5785

Sigma-Aldrich

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate

meets USP testing specifications

Synonym(s):

L-(−)-Noradrenaline (+)-bitartrate salt monohydrate

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · C4H6O6 · H2O
CAS Number:
108341-18-0
Molecular Weight:
337.28
MDL number:
MFCD00150449
UNSPSC Code:
51391722
PubChem Substance ID:
24897754
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

Quality Level

200

form

solid

application(s)

pharmaceutical (small molecule)

SMILES string

O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.NC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

InChI key

LNBCGLZYLJMGKP-LUDZCAPTSA-N

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Related Categories

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000319570
0000319568
0000319569
SLCM1982
SLCF1769

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Asuka Inoue et al.
Cell, 177(7), 1933-1947 (2019-06-05)
Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence selectivity determinants remain elusive. Here
Pooja R Patel et al.
Journal of bioanalysis & biomedicine, 7(3), 75-80 (2015-07-15)
To determine the role of norepinephrine (NE) on DNA damage and reactive oxygen species (ROS) generation in ovarian surface epithelial cells. Non-tumorigenic, immortalized ovarian surface epithelial cells were treated with NE, bleomycin, and bleomycin followed by NE. The comet assay
Brian C Jensen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 382(5-6), 475-482 (2010-09-22)
Alpha-1-adrenergic receptors (α1-ARs) regulate coronary arterial blood flow by binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing vasoconstriction when the endothelium is disrupted. Among the three α1-AR subtypes (α1A, α1B, and α1D), the α1D subtype predominates in human epicardial coronary
Kanako Iwasaki et al.
Frontiers in neuroscience, 12, 535-535 (2018-08-23)
Sleep/wake behavior is regulated by distinct groups of neurons, such as dopaminergic, noradrenergic, and orexinergic neurons. Although monoaminergic neurons are usually considered to be wake-promoting, the role of serotonergic neurons in sleep/wake behavior remains inconclusive because of the effect of
Alicia Villacampa et al.
Aging and disease (2024-07-16)
Premature vascular aging and endothelial cell senescence are major risk factors for cardiovascular diseases and atherothrombotic disturbances, which are main complications of both acute and long COVID-19. The S protein of SARS-CoV2, which acts as the receptor binding protein for
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