73120

4-Nitrobenzoyl chloride

for HPLC derivatization, LiChropur^™, ≥99.0% (GC)

• Linear Formula: O₂NC₆H₄COCl
• CAS Number: 122-04-3
• Molecular Weight: 185.56
• Beilstein: 473192
• EC Number: 204-517-4
• MDL number: MFCD00007345
• UNSPSC Code: 12000000
• PubChem Substance ID: 329764631
• NACRES: NA.22

Properties

• grade: for HPLC derivatization
• Quality Level: 100
• Assay: ≥99.0% (GC)
• form: crystals
• quality: LiChropur^™
• technique(s): HPLC: suitable
• ign. residue: ≤0.05% (as SO₄)
• bp: 202-205 °C/105 mmHg (lit.)
• mp: 71-74 °C (lit.); 71-74 °C
• SMILES string: [O-][N+](=O)c1ccc(cc1)C(Cl)=O
• InChI: 1S/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H
• InChI key: SKDHHIUENRGTHK-UHFFFAOYSA-N

Description

General description

4-Nitrobenzoyl chloride is a derivatization reagent. It reacts with L-glutamic acid undergoing methylation using formaldehyde, synthesizing N-(4-methylaminobenzoyl)glutaminic acid.

Application

4-Nitrobenzoyl chloride was used in separating polyhydric alcohols using HPLC. It was used in snythesizing cellulose benzotates by adding to cellulose/1-allyl-3-methylimidazolium chloride followed by characterization using FT-IF, ¹H-NMR and ¹³C-NMR spectroscopy. It may be used in synthesizing 1-aryloxyacetyl-4-(4-nitrobenzoyl)-thiosemicarbazides under phase transfer catalysis and microwave irradiation with ammonium thiocyanate and aryloxyacetic acid hydrazides.

Other Notes

Derivatization of hydroxy groups for HPLC

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H290,H314
• Precautionary Statements: P234 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): 215.6 °F - closed cup
• Flash Point(C): 102 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves