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201316

Sigma-Aldrich

Quinaldine Red

Dye content 95 %

Synonym(s):

2-(4-Dimethylaminostyryl)-1-ethylquinolinium iodide

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About This Item

Empirical Formula (Hill Notation):
C21H23IN2
CAS Number:
117-92-0
Molecular Weight:
430.33
Beilstein:
3798055
EC Number:
204-221-5
MDL number:
MFCD00011968
UNSPSC Code:
12171500
PubChem Substance ID:
24852005
NACRES:
NA.47

form

powder or crystals

Quality Level

200

composition

Dye content, 95%

technique(s)

titration: suitable

solubility

ethanol: 1 mg/mL, clear, dark red

λmax

528 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[I-].CC[n+]1c(\C=C\c2ccc(cc2)N(C)C)ccc3ccccc13

InChI

1S/C21H23N2.HI/c1-4-23-20(16-12-18-7-5-6-8-21(18)23)15-11-17-9-13-19(14-10-17)22(2)3;/h5-16H,4H2,1-3H3;1H/q+1;/p-1

InChI key

JOLANDVPGMEGLK-UHFFFAOYSA-M

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Application

Quinaldine Red has been used as a fluorescent probe for α1-acid glycoprotein (AAG).

Biochem/physiol Actions

Quinaldine Red (2-(p-Dimethylaminostyryl) quinoline ethiodide) is a very dark red or reddish-black colored powder. It has been used mainly for regulation of cell proliferation, in diagnostic agents of disease related with amyloid accumulation, detecting enzyme activity and dental bleaching materials. In addition, quinaldine red also been implicated in treatment of allodynia and virus infectious diseases. It is colorless at pH 1.4 and red at pH 3.2.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000343192
SHBR3347
0000343192
SHBQ6146
0000233064

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Cationic Drug Pharmacokinetics in Diseased Livers Determined by Fibrosis Index, Hepatic Protein Content, Microsomal Activity, and Nature of Drug
Hung D Y
Journal of Pharmacology and Experimental Therapeutics, 301, 1079-1087 (2002)
Selective plasma protein binding of antimalarial drugs to a1-acid glycoprotein
Zsila F
Bioorganic & Medicinal Chemistry, 3759-3772 (2008)
Paul Zuck et al.
Analytical biochemistry, 342(2), 254-259 (2005-06-14)
Miniaturization of high-throughput screening (HTS) assays has several obvious advantages, including increased throughput and lower cost by reduction in reagent consumption. Although absorbance assays are widely used in research laboratories, their application for HTS in a low-volume format has been
A I Ivanov et al.
Clinical and experimental medicine, 2(3), 147-155 (2002-11-26)
The acute-phase response alters the composition of carrier proteins in plasma, which may affect the blood deposition and transport of biomediators and drugs. The effect of the acute-phase response on the ligand binding ability of plasma was studied in leukemic
H Imamura et al.
Pharmaceutical research, 11(4), 566-570 (1994-04-01)
We examined different fluorescent probes suitable for fluorometric determination of alpha 1-acid glycoprotein (AGP) in serum. Quinaldine red (QR) was shown to bind strongly and selectively to AGP. Taking advantage of the enhanced fluorescence of QR in the presence of
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