Stabilin-2 (Stab2; FEEL-2; and HARE) is a phosphatidylserine receptor that is localized to hepatic sinusoidal endothelial cells. It is a large protein containing a linker domain, two laminin EGF-like domains, four FAS1 domains, and six EGF-like domains, enabling stabilin-2 to perform multiple functions. Stabilin-2 is primarily studied for its role as a scavenger receptor that is involved in the clearance of metabolic waste products, which may include hyaluronic acid, heparin, advanced glycation end-products, acetylated LDL, and chondroitin sulfates. Previous studies have also suggested that stabilin-2 may play a role in cell adhesion processes.
Immunogen
Partially purified rat Stabilin-2 from the HA binding region.
Application
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in spleen, liver, and lymph node tissues. (Weigel, P., et al. (2003). Journal of Biological Chemistry. 278(11):9808–9812.)
This Anti-Stabilin-2 Antibody, clone mAb-174 is validated for use in Western Blotting, IHC for the detection of Stabilin-2.
Quality
Evaluated by Western Blot in rat spleen tissue lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected Stabilin-2 on 10 µg of rat spleen tissue lysate.
Target description
~190 kDa observed. The calculated molecular weight of this protein is 155 kDa, but can be observed at ~190 kDa due to high glycosylation. An uncharacterized band appears at ~20 kDa in some lysates.
Physical form
Format: Purified
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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