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MAB5456

Sigma-Aldrich

Anti-Gonadotropin-Releasing Hormone Antibody, NT, clone HU11B

ascites fluid, clone HU11B, Chemicon®

Synonym(s):

GnRH, Luteinizing Hormone-Releasing Hormone, LHRH

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

antibody form

ascites fluid

antibody product type

primary antibodies

clone

HU11B, monoclonal

species reactivity

hamster, shrimp, mouse, monkey, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable (paraffin)

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

mouse ... Gnrh1(14714)

Specificity

Reacts with mammalian Gonadotropin-releasing hormone.

Immunogen

Epitope: N-terminus
Mouse GnRH (QHWSYGLRPG) conjugated to bovine thyroglobulin.

Application

Immunohistochemistry on 4% paraformaldehyde fixed tissue sections.

Immunocytochemistry

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Hormones & Receptors
This Anti-Gonadotropin-Releasing Hormone Antibody, N-terminus, clone HU11B is validated for use in IH(P) for the detection of Gonadotropin-Releasing Hormone.

Physical form

Ascites fluid. Liquid. Contains no preservative.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Santiago E Charif et al.
Physiological reports, 5(19) (2017-10-19)
Females of the South American plains vizcacha, Lagostomus maximus, show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arising from the reactivation of the hypothalamic-hypophyseal-ovary (H.H.O.) axis. Estradiol
S E Rietema et al.
Reproduction, fertility, and development, 31(11), 1682-1691 (2019-09-13)
Rams respond to acute nutritional supplementation by increasing the frequency of gonadotrophin-releasing hormone (GnRH) pulses. Kisspeptin neurons may mediate the effect of environmental cues on GnRH secretion, so we tested whether the ram response to nutrition involves activation of kisspeptin
Aleisha M Moore et al.
Scientific reports, 8(1), 2242-2242 (2018-02-06)
Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in the regulation of fertility. The ability to detect features of KNDy neurons that are essential for fertility may require three-dimensional (3D) imaging of the complete population.
Diana E Peragine et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(5), 1207-1212 (2017-01-18)
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)]
Lixian Cheng et al.
Endocrinology, 157(12), 4875-4887 (2016-10-05)
Adipose tissue plays an important role in regulating female fertility, owing to not only its energy stores but also the endocrine actions of secreted adipokines. As one of the adipokines, adiponectin is almost exclusively secreted from the fat, and its

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