MAB2291
Anti-Integrin α3 Antibody, cytoplasmic domain, clone 54B3
clone 54B3, Chemicon®, from mouse
Synonym(s):
CD49c
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About This Item
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
54B3, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
General description
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha 6, two cytoplasmic variants, A and B, have been identified.
MAB2291 is a mouse monoclonal generated to a synthetic peptide in the cytoplasmic domain of integrin alpha 3B.
Specificity
Anti-Integrin alpha 3B recognizes the cytoplasmic domain of integrin alpha 3B. Integrin alpha 3B is present in the microvascular structures in brain and heart.
SPECIES REACTIVITIES:
Although untested, a broad species reactivity is expected due to the conserved nature of the epitope.
SPECIES REACTIVITIES:
Although untested, a broad species reactivity is expected due to the conserved nature of the epitope.
Immunogen
Epitope: cytoplasmic domain
Synthetic peptide: CTRYYQIMPKYHAVRIREEERYPPPGSTLPTKK
Application
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
This Anti-Integrin α3 Antibody, cytoplasmic domain, clone 54B3 is validated for use in WB, IC, IH for the detection of Integrin α3.
Western Blotting
Immunocytochemistry
Immunohistochemistry
Optimal working dilutions must be determined by the end user.
Immunocytochemistry
Immunohistochemistry
Optimal working dilutions must be determined by the end user.
Physical form
Format: Purified
Purified. Liquid in PBS containing 0.1% sodium azide.
Storage and Stability
Store at 2-8°C, or in small aliquots at -20°C.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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