Skip to Content
Merck
All Photos(2)

Documents

ABC471

Sigma-Aldrich

Anti-KLF15 Antibody

1.0 mg/mL, from rabbit

Synonym(s):

Krueppel-like factor 15, Kidney-enriched krueppel-like factor, KLF15

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

primate (based on 100% sequence homology), bat (based on 100% sequence homology), baboon (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), monkey (based on 100% sequence homology)

concentration

1.0 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_054798

UniProt accession no.

Q9UIH9

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KLF15(28999)

General description

KLF15, also known as Krueppel-like factor 15, Kidney-enriched krueppel-like factor, and encoded by the gene KLF15/KKLF, is a transcriptional regulator that affects expression in a wide variety of developmental and cellular systems. These include glial cell differentiation, cardiac circadian expression regulation, podocyte differentiation, glomerular visceral epithelial cell differentiation, glucose transport, and negative regulation of Peptidyl-lysine acetylation. KLF15 is highly expressed in liver, skeletal muscle, cardiomyocytes and kidney cells. KLF15 is a biomarker in patients with non-ischemic cardiomyopathy, glomerular disease, and aortic aneurysm. In such patients KLF15 expression is severely down regulated. KLF15 deficiency affects the cardiac rhythm and may play a role in ventricular arrhythmias and pathological conditions of the heart.

Immunogen

Epitope: Unknown
KLH-conjugated linear peptide corresponding to human KLF15.

Application

Anti-KLF15 Antibody detects level of KLF15 & has been published & validated for use in KLF15.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected KLF15 in human liver tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Quality

Evaluated by Western Blotting in human skeletal muscle tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected KLF15 in 10 µg of human skeletal muscle tissue lysate.

Target description

~46 kDa observed

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Yue-Tong Guo et al.
Journal of the American Heart Association, 10(16), e020554-e020554 (2021-08-06)
Background Adventitial remodeling is a pathological hallmark of hypertension that results in target organ damage. Activated adventitial fibroblasts have emerged as critical regulators in this process, but the precise mechanism remains unclear. Methods and Results Interleukin 11 (IL-11) knockout and
Xiangchen Gu et al.
Kidney international, 92(5), 1178-1193 (2017-06-28)
Large epidemiological studies clearly demonstrate that multiple episodes of acute kidney injury contribute to the development and progression of kidney fibrosis. Although our understanding of kidney fibrosis has improved in the past two decades, we have limited therapeutic strategies to
Yiqing Guo et al.
Journal of the American Society of Nephrology : JASN, 29(10), 2529-2545 (2018-08-26)
Podocyte injury is the hallmark of proteinuric kidney diseases, such as FSGS and minimal change disease, and destabilization of the podocyte's actin cytoskeleton contributes to podocyte dysfunction in many of these conditions. Although agents, such as glucocorticoids and cyclosporin, stabilize

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service