5.31038

TAT-Beclin-1, Scrambled

≥95% (HPLC), powder, Beclin-1 activator, Calbiochem^®

• Synonym(s): Beclin-1 Activator I, TAT-Beclin-1, Scrambled, H₂N-YGRKKRRQRRR-GG-VGNDFFINHETTGFATEW-CO₂H
• Empirical Formula (Hill Notation): C₁₆₄H₂₅₁N₅₇O₄₅
• Molecular Weight: 3741.10
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Beclin-1 Activator I, TAT-Beclin-1, Scrambled,
• Assay: ≥95% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 25 mg/mL
• storage temp.: 2-8°C

Description

General description

Beclin-1 (267-284), a randomly shuffled peptideis made cell-permeable by attaching covalently to a human immunodeficiency virus(HIV)-1 Tat protein transduction domain via a diglycine linker. Beclin-1activating peptide I, TAT-Beclin-1, is observed to promote autophagy invitro and in vivo in pharmacological research.

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly-Gly~Val-Gly-Asn-Asp-Phe-Phe-Ile-Asn-His-Glu-Thr-Thr-Gly-Phe-Ala-Thr-Glu-Trp-OH

Other Notes

Liu, Y., et al. 2013. Proc. Natl. Acad. Sci. USA110, 20364.
Shoji-Kawata, S., et al. 2013. Nature.494, 201.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable