A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.
Biochem/physiol Actions
Primary Target P2Y₁₂
Reversible: no
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Liu, O., et al. 2012. PLoS One.7, e51707.
Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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