5.04845

Ro 25-6981 Maleate Salt

• Synonym(s): Ro 25-6981 Maleate Salt, [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
• Empirical Formula (Hill Notation): C₂₂H₂₉NO₂ · xC₄H₄O₄
• CAS Number: 169274-78-6
• Molecular Weight: 339.47 (free base basis)
• UNSPSC Code: 12352200

Properties

• Assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 0.009 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: H₂O: 25 mM
• storage temp.: 2-8°C
• InChI: 1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
• InChI key: WVZSEUPGUDIELE-HTAPYJJXSA-N

Description

General description

A potent, activity-dependent antagonist highly selective for GluN1/NR2B subtype NMDA receptors (IC50 = 0.009 and 52 µM for NR2B and NR2A subtype receptors respectively). Commonly used for studying brain functions and disorders involving neurotransmissions mediated by GluN1/NR2B subtype NMDA receptors (learning and memory, neuroplasticity, neurotoxicity, neuropathic pain, addiction, and neurogenesis enhancement).

Biochem/physiol Actions

Primary Target
GluN1/NR2B receptors

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Qi, Y., et al. 2013. Cereb. Cortex.23, 932.
Soloviova, A., et al. 2012. Exp. Biol. & Med.153, 764.
Solovyeva, A., et al. 2012. Neurosci. & Behav. Physiol.42, 456.
Chazot, L., et al. 2004. Curr. Med. Chem.11, 389.
Lynch, R., et al. 2001. Eur. J. Pharmacol.416, 185.
Fischer, G., et al. 1997. J. Pharmacol. Exp. Ther.283, 1285.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable