A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Yagoda, N., et al. 2007. Nature447, 864.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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