T-905

Thioridazine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₂₁H₂₆N₂S₂
• CAS Number: 50-52-2
• Molecular Weight: 370.57
• MDL number: MFCD00242875
• UNSPSC Code: 41116107
• PubChem Substance ID: 329826893
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1
• InChI: 1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
• InChI key: KLBQZWRITKRQQV-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)

Description

General description

An analytical reference standard applicable for use as starting material in calibrators or controls for thioridazine testing methods by LC-MS/MS or GC-MS. Thioridazine is a treatment for schizophrenia sold under trade names Mellaril, Novoridazine, and Thioril.

Application

• Fluorescence Chemosensor Development: Thioridazine solution has been utilized in the synthesis and application of an aldazine-based fluorescence chemosensor. This innovation allows for the sequential detection of Cu²⁺ and biological thiols in aqueous solutions and living cells, enhancing analytical capabilities in biochemical and medical research (Jia et al., 2016).


• Voltammetric Analysis Enhancement: Research involving thioridazine solution has led to the development of a modified glassy carbon electrode with immobilized cobalt nanoparticles. This advancement facilitates the sensitive voltammetric determination of thioridazine, improving detection methods in pharmaceutical and clinical settings (Shahrokhian et al., 2009).


• Microencapsulation Techniques: Thioridazine has been applied in pioneering work on the microencapsulation of drugs using gold nanoparticles. This technique aims to enhance drug delivery systems by improving the bioavailability and controlled release of antipsychotic medications, offering significant benefits for long-term psychiatric treatment (Lai et al., 2006).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup