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850538P

Avanti

Facade™-TEG

3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane, powder

Synonym(s):

FA-5

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About This Item

Empirical Formula (Hill Notation):
C48H84O21
CAS Number:
1429405-97-9
Molecular Weight:
997.17
UNSPSC Code:
12161902
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

mol wt

997.17 g/mol

packaging

pkg of 1 × 25 mg (850538P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 850538P

technique(s)

protein quantification: suitable

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@]12[C@]([C@](CC[C@@H](OCCO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C4)(C)[C@]4([H])C[C@H]2OCCO[C@@H]5[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O5)([H])C[C@H](OCCO[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)[C@@]7(C)[C@@]1([H])CC[C@@H]7[C@H](C)CCC

General description

Facade™ TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane) carries three sugar (maltoside/glucoside) attachments on the steroid backbone.

Biochem/physiol Actions

Facade™ TEG/FA-5 (3α,7α,12α-tri-((O-β-D-glucopyranosyl)ethyloxy)-cholane), a sugar-based facial amphiphile can be used in membrane protein (MP) crystallization experiments. Facade-TEG helps to enhance the thermostability of type II cannabinoid receptor (CB2). Facade detergents acts as the best platform for biophysical characterization of G protein-coupled receptor (GPCR).

Packaging

5 mL Amber Glass Screw Cap Vial (850538P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
Facade is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ryan L Beckner et al.
The Journal of biological chemistry, 295(1), 181-190 (2019-11-30)
G protein-coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can help advance the rational design
Designing facial amphiphiles for the stabilization of integral membrane proteins.
Qinghai Zhang et al.
Angewandte Chemie (International ed. in English), 46(37), 7023-7025 (2007-08-11)
Sung Chang Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), E1203-E1211 (2013-03-13)
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from conventional detergents and previously developed FAs. The unique FAs stabilize MPs and

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