QBD10009

Biotin-dPEG^®₄-TFP ester

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₂₇H₃₇F₄N₃O₈S
• Molecular Weight: 639.66
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823873
• NACRES: NA.22

Properties

• Assay: >90%
• form: solid or viscous liquid
• reaction suitability: reaction type: Biotinylations; reaction type: Biotinylations; reactivity: amine reactive; reagent type: cross-linking reagent
• polymer architecture: shape: linear; functionality: monofunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O
• InChI key: XBGOXOZYGAXNFP-UHFFFAOYSA-N

Description

Application

Biotin-dPEG^®₄-TFP ester is an amphiphilic and hydrolytically stable compound used as a cross-linking reagent in biotinylations reactions.[1]

Features and Benefits

Biotin-dPEG^®₄-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyzes more slowly than NHS ester in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG^®₄-TFP ester has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. The PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable