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930237

Sigma-Aldrich

2,5-dioxopyrrolidin-1-yl (2,5-dichlorobenzoyl)glycyl-L-leucinate

≥95%

Synonym(s):

CANDDY_MLN Tag NHS ester

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About This Item

Empirical Formula (Hill Notation):
C19H21Cl2N3O6
Molecular Weight:
458.29
UNSPSC Code:
12352209
NACRES:
NA.21

Quality Level

100

Assay

≥95%

form

powder

storage temp.

2-8°C

SMILES string

ClC1=CC=C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2=O)=O)=O)CC(C)C)=O)=O)=C1

Related Categories

Application

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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