Cyanogen bromide is widely used in protein immobilization[1][2] and cleavage.[3]
Under von Braun reaction conditions, CNBr reacts with tertiary amines to yield respective organocyanamides.[4][5]
It can also be used to synthesize organic intermediates like cyanuric bromide, derivatives of urea, guanidine, creatine, aryl nitriles, and a variety of heterocyclic compounds.[6][7][8][9]
Other Notes
Reagent for the selective cleavage of peptide bonds (e.g. methionine)[10][11]
Herein we describe a procedure for the in situ cyanogen bromide cleavage of N-terminally blocked proteins which have been immobilised onto the glass fiber sample disk of the gas-phase sequencer. In this manner, new amino terminii suitable for automated Edman
Cyanogen bromide (CNBr).
Kumar V
Synlett, 2005(10), 1638-1639 (2005)
Synthesis of hindered chiral guanidine bases starting from (S)-(N, N-dialkyl-aminomethyl) pyrrolidines and BrCN.
Kohn U, et al.
Tetrahedron Asymmetry, 17(5), 811-818 (2006)
Straightforward Conversion of Alcohols into Nitriles.
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