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S1002

Sigma-Aldrich

Saccharin sodium salt hydrate

≥98.0% (titration)

Synonym(s):

2,3-Dihydro-3-oxobenzisosulfonazole sodium salt, 2-Sulfobenzoic acid imide sodium salt, o-Sulfobenzimide sodium salt, Saccharin soluble

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About This Item

Empirical Formula (Hill Notation):
C7H4NNaO3S · xH2O
CAS Number:
82385-42-0
Molecular Weight:
205.17 (anhydrous basis)
Beilstein:
3599229
EC Number:
204-886-1
MDL number:
MFCD00149605
UNSPSC Code:
12164504
PubChem Substance ID:
24899456
NACRES:
NA.25

Quality Level

200

Assay

≥98.0% (titration)

sweetness

300 × sucrose

SMILES string

[Na+].[H]O[H].[O-]C1=NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S.Na.H2O/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;/h1-4H,(H,8,9);;1H2/q;+1;/p-1

InChI key

ILJOYZVVZZFIKA-UHFFFAOYSA-M

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Application


  • Application of a colorimetric technique in quality control for printed pediatric orodispersible drug delivery systems containing propranolol hydrochloride.: This article discusses the use of a colorimetric method to ensure quality control in 3D printed pediatric drug delivery systems, incorporating saccharin sodium salt hydrate as a sweetener, emphasizing its role in improving the taste and compliance of pediatric medications (Vakili et al., 2016).

Biochem/physiol Actions

′First generation′ synthetic sugar alternative that has been studied for its carcinogenic potential.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Robert A Boakes et al.
Physiology & behavior, 218, 112822-112822 (2020-02-01)
Rats first given 24-h access to 10% sucrose for 4 or 12 days (Stage 1) were then switched to a saccharin solution for a 12-day Stage 2. The initial result of this switch was that these Sucrose groups drank less
Simone Rehn et al.
Physiology & behavior, 207, 15-27 (2019-05-06)
When animals are given access to a palatable food or drink on some days but not on others, the amount they consume can far exceed the daily amounts consumed by controls given daily access. A previous study demonstrated such bingeing
Valentina Sabino et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 34(6), 1482-1493 (2008-10-24)
Sigma-Receptors (SigRs) have been implicated in behavioral and appetitive effects of psychostimulants and may also modulate the motivating properties of ethanol. This study tested the hypothesis that SigRs modulate ethanol reinforcement and contribute to excessive ethanol intake. The effects of
Rhian Alice Ceredig et al.
Frontiers in molecular neuroscience, 12, 324-324 (2020-03-03)
Neuropathic pain is a challenging condition for which current therapies often remain unsatisfactory. Chronic administration of β2 adrenergic agonists, including formoterol currently used to treat asthma and chronic obstructive pulmonary disease, alleviates mechanical allodynia in the sciatic nerve cuff model
Deirdre M McCarthy et al.
Scientific reports, 10(1), 11974-11974 (2020-07-21)
The use of non-nutritive sweeteners such as saccharin is widely prevalent. Although saccharin is considered safe for human consumption, it produces behavioral changes in experimental animals. We report that saccharin's behavioral effects are much more pervasive than currently recognized. In
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