Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
PHR1088
Azithromycin
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Azithromycin dihydrate, 1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10- trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylohexopyranosyl]oxy]-, [2R-(2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R)]- dihydrate, N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A, CP-62993
About This Item
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to Ph. Eur. Y0000306
traceable to USP 1046056
API family
azithromycin
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
-10 to -25°C
SMILES string
O.O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O
InChI
1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1../s1
InChI key
SRMPHJKQVUDLQE-KUJJYQHYSA-N
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General description
Application
Biochem/physiol Actions
Analysis Note
Other Notes
Footnote
related product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Certificates of Analysis (COA)
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Customers Also Viewed
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Helpful?
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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What is the assay purity, active fraction and 1-water content of Azithromycin?
1 answer-
This product is tested against, and is traceable to, the current EP and USP standard. The item is intended for use as an analytical standard. The purity and moisture content are lot specific and reported in the product Certificate of Analysis. A brief review of recent lots indicate a purity of approximately 95% on an 'as is' basis and a moisture content of 4.0 - 4.5%. The active fraction is not determined. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sial/phr1088#product-documentationHelpful?
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What is the maximum solubility of Azithromycin in DMSO?
1 answer-
This product is soluble in DMSO at approximately 5 mg/mL. Other solvents include ethanol and dimethyl formamide (DMF) at approximately 16 mg/mL.
Helpful?
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What is the solubility of the product AZITHROMYCIN (PHR1088)?
1 answer-
The product is soluble in methanol, DMSO (greater than 20 mg/mL), ethanol, chloroform, and dimethylchloride.
Helpful?
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PHR1088 Supelco Azithromycin How much is the measured water content and active fraction of the product?
1 answer-
This product is listed as a dihydrate. A brief survey of recent lots reveals a general range of 4.1 - 4.4% H2O by Karl Fischer Titration. The water content is a lot specific. Please see the link below to access the Certificate of Analysis for a specific lot:
https://www.sigmaaldrich.com/searchHelpful?
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