WHAWB129241
QIAcard™ FTA™ DMPK Cards
FTA DMPK-A card, 4 sample areas per card, pack of 100 cards
Synonym(s):
QIAcard™ FTA™ DMPK-A (100), whatman dmpk, whatman fta
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
41105500
NACRES:
NB.22
material
white
manufacturer/tradename
Qiagen WB129241
packaging
pack of 100 cards
Looking for similar products? Visit Product Comparison Guide
General description
Drug Metabolism (DM) Pharmacokinetic (PK) studies provide crucial insight into the way drug candidates behave in the body. These studies are a critical step in drug development.
QIAcard™ FTA™ DMPK Cards for Drug Metabolism Pharmacokinetics enable microvolume sampling with only 10 to 20 µl per sample and are designed for use with blood samples. The cards can also be used with colorless samples such as plasma, cerebrospinal fluid and urine.
QIAcard™ FTA™ DMPK-A contains impregnated chemicals enabling protein denaturation to inactivate endogenous enzymes. Cell lysis releases endogenous cellular materials onto card. Stabilization of DNA allows resampling of blood spot for pharmacogenomics. Impregnated chemicals may interfere with mass spectrometry detection e.g. ion suppression.
QIAcard™ FTA™ DMPK Cards for Drug Metabolism Pharmacokinetics enable microvolume sampling with only 10 to 20 µl per sample and are designed for use with blood samples. The cards can also be used with colorless samples such as plasma, cerebrospinal fluid and urine.
QIAcard™ FTA™ DMPK-A contains impregnated chemicals enabling protein denaturation to inactivate endogenous enzymes. Cell lysis releases endogenous cellular materials onto card. Stabilization of DNA allows resampling of blood spot for pharmacogenomics. Impregnated chemicals may interfere with mass spectrometry detection e.g. ion suppression.
Features and Benefits
- DBS microvolume sampling requires only 10—20 μl per sample.
- Consistent data are obtained through more serial sampling from individual animals.
- Less reliance on composite data.
- The 3-step DBS procedure is more straightforward than the cumbersome centrifugation, isolation and clean-up of plasma.
- Conveys greater analyte stability through on-substrate clean-up, especially for enzyme-sensitive compounds.
- Room temperature stability saves on cost of dry ice shipments and allows remote sampling.
Other Notes
Analysis is primarily with HPLC or UHPLC followed by MS/MS detection, direct desorption MS techniques such as DESI. Methanol or aqueous/organic mixtures have been shown to work well for small molecules and aqueous buffers are recommended for proteins. Select a good solvent for the analyte while maintaining compatibility with the HPLC conditions to be used. The choice of DMPK card depends on many factors such as the analyte chemical structure, extraction solvent and analysis workflow.
Field of Use : For internal research use only
Field of Use : For internal research use only
Legal Information
FTA is a trademark of Qiagen Group
QIAcard is a trademark of Qiagen Group
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service