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T111

Sigma-Aldrich

8-(Diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride

≥98%

Synonym(s):

TMB 8 hydrochloride, TMB-8 · HCl

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About This Item

Linear Formula:
(CH3O)3C6H2CO2(CH2)8N(C2H5)2 · HCl
CAS Number:
53464-72-5
Molecular Weight:
431.99
Beilstein:
5466611
EC Number:
258-574-5
MDL number:
MFCD00012502
UNSPSC Code:
12352100
PubChem Substance ID:
57654652
NACRES:
NA.22

Assay

≥98%

form

powder

mp

94-97 °C (lit.)

SMILES string

Cl[H].CCN(CC)CCCCCCCCOC(=O)c1cc(OC)c(OC)c(OC)c1

InChI

1S/C22H37NO5.ClH/c1-6-23(7-2)14-12-10-8-9-11-13-15-28-22(24)18-16-19(25-3)21(27-5)20(17-18)26-4;/h16-17H,6-15H2,1-5H3;1H

InChI key

KFJZVXKPPQIYCG-UHFFFAOYSA-N

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Application

  • Pharmacologically active inhibitor of hepatitis C virus life cycle

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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María Angeles Sánchez-Sampedro et al.
Journal of plant physiology, 162(10), 1177-1182 (2005-11-01)
Elimination of calcium ions from the medium of cell cultures of Silybum marianum (L.) Gaertn increased flavonolignan production. Silymarin accumulation was not altered by treatment of cultures with the calcium ionophore A23187. The specific Ca2+ chelator, EGTA, enhanced the silymarin
Byung-Hwan Lee et al.
Neuropharmacology, 52(4), 1139-1150 (2007-01-30)
We previously demonstrated that 20(S)-ginsenoside Rg(3) (Rg(3)), one of the active components of Panax ginseng, non-competitively inhibits 5-HT(3A) receptor channel activity on extracellular side of the cell. Here, we sought to elucidate the molecular mechanisms underlying Rg(3)-induced 5-HT(3A) receptor regulation.
Agata Adamczyk et al.
Folia neuropathologica, 43(3), 139-142 (2005-10-26)
Our previous studies indicated that Alzheimer's disease (AD) related amyloid beta peptide (Abeta) significantly altered muscarinic cholinergic receptor (mChR) signaling on the level of G protein regulated phospholipase C (PLC) leading to the lower formation of inositol-1,4,5-triphosphate (IP3) and diacylglycerol
P Fang et al.
Acta physiologica (Oxford, England), 199(1), 53-61 (2010-01-20)
The aim of this study was to determine the effects of motilin on [Ca(2+)](i) regulation and its underlying molecular mechanism in cultured antral smooth muscle cells (ASMCs). Antral cells were isolated and cultured from neonatal rats, and then the [Ca(2+)](i)
Jafar Vatanparast et al.
European journal of pharmacology, 571(2-3), 81-87 (2007-06-30)
We have previously reported that paraoxon, an organophosphate compound, at submicromolar concentrations effectively suppresses Ca2+ action potentials and modulates the activity of snail neurons. This effect was unrelated to acetylcholinesterase inhibition but was found to involve the direct or indirect
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