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543918

Sigma-Aldrich

2-Chloropyridine-4-carboxylic acid

97%

Synonym(s):

2-Chloroisonicotinic acid

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About This Item

Empirical Formula (Hill Notation):
C6H4ClNO2
CAS Number:
Molecular Weight:
157.55
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

97%

mp

246 °C (dec.) (lit.)

SMILES string

OC(=O)c1ccnc(Cl)c1

InChI

1S/C6H4ClNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3H,(H,9,10)

InChI key

QXCOHSRHFCHCHN-UHFFFAOYSA-N

Application

2-Chloropyridine-4-carboxylic acid may be used to synthesize 11-oxo-11 H-pyrido[2,1-b]quinazoline-7-carboxylic acid1 and 3-oxospiro[(aza)isobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide derivatives.
Used in monocomposite films.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro [6-azaisobenzofuran-1 (3H), 1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.
Haga Y, et al.
Bioorganic & Medicinal Chemistry, 17(19), 6971-6982 (2009)
11-Oxo-11H-pyrido [2, 1-b] quinazoline-8-carboxylic acid, an orally active antiallergy agent.
Schwender CF, et al.
Journal of Medicinal Chemistry, 22(1), 114-116 (1979)
Manal H Al Khabbas et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 44, 209-217 (2017-10-03)
A number of new mono- and dihydroxypyridinethione ligands have been synthesized via reaction of dimethylamine and amino acid esters with the active amide obtained from the reaction of 1-hydroxy-2-pyridinethione-4-carboxylic acid (1) and 1,1'-carbonyldiimidazole in DMF. Moreover, the lead complexes of
Chemistry of Materials, 16, 2363-2368 (2004)

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