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498203

Sigma-Aldrich

3,3,3-Trifluoropropionic acid

98%

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About This Item

Linear Formula:
CF3CH2CO2H
CAS Number:
2516-99-6
Molecular Weight:
128.05
MDL number:
MFCD00153292
UNSPSC Code:
12352100
PubChem Substance ID:
24873178
NACRES:
NA.22

Assay

98%

refractive index

n20/D 1.333 (lit.)

bp

145 °C/746 mmHg (lit.)

mp

9.7 °C (lit.)

density

1.45 g/mL at 25 °C (lit.)

SMILES string

OC(=O)CC(F)(F)F

InChI

1S/C3H3F3O2/c4-3(5,6)1-2(7)8/h1H2,(H,7,8)

InChI key

KSNKQSPJFRQSEI-UHFFFAOYSA-N

Application

3,3,3-Trifluoropropionic acid may be used in the synthesis of:
  • 2,2,2-trifluoroethyl 3,3,3-trifluoroprionate
  • ethyl 3,3,3-trifluoroprionate
  • N-trifluoropropionyl-D-mannosamine
  • 3,3,3-trifluoropropanoyl chloride

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H332,H412

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

198.0 °F - closed cup

Flash Point(C)

92.22 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis of ethyl 3,3,3-trifluoropropionate from 2-bromo-3,3,3-trifluoropropene.
Inoue M, et al.
Journal of Fluorine Chemistry, 167, 135-138 (2014)
Bi-phobic cellulose fibers derivatives via surface trifluoropropanoylation.
Cunha AG, et al.
Langmuir, 23(21), 10801-10806 (2007)
157 nm Resist Materials: A Progress Report.
Chiba T, et al.
J. Photopolym. Sci. Technol., 13(4), 657-664 (2000)
Yanbin Pan et al.
Carbohydrate research, 339(12), 2091-2100 (2004-07-29)
N-Acetyl-D-neuraminic acid (NeuNAc) aldolase is an important enzyme for the metabolic engineering of cell-surface NeuNAc using chemically modified D-mannosamines. To explore the optimal substrates for this application, eight N-acyl derivatives of D-mannosamine were prepared, and their accessibility to NeuNAc aldolase
Bifan Chen et al.
Analytical chemistry, 91(18), 11661-11669 (2019-08-24)
Antibody-drug conjugates (ADCs) are designed to combine the target specificity of monoclonal antibodies and potent cytotoxin drugs to achieve better therapeutic outcomes. Comprehensive evaluation of the quality attributes of ADCs is critical for drug development but remains challenging due to
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