- Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors.
Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors.
Bioorganic & medicinal chemistry letters (2006-11-11)
Jun-Ichi Sakamoto, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I P J Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Yasuaki Esumi, Ken Hatano, Daiyo Terunuma, Koji Matsuoka
PMID17095224
RESUMEN
An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with alpha-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases.
MATERIALES