1437202

1-Metil-2-pirrolidinona

United States Pharmacopeia (USP) Reference Standard

• Sinónimos: 1-Metil-2-pirrolidona, N-Metil-2-pirrolidona, NMP
• Fórmula empírica (notación de Hill): C₅H₉NO
• Número CAS: 872-50-4
• Peso molecular: 99.13
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750275
• MDL number: MFCD00003193
• Beilstein/REAXYS Number: 106420

Propiedades

• grade: pharmaceutical primary standard
• agency: USP
• vapor density: 3.4 (vs air)
• vapor pressure: 0.29 mmHg ( 20 °C), 0.99 mmHg ( 40 °C)
• form: liquid
• autoignition temp.: 518 °F
• expl. lim.: 9.5 %
• manufacturer/tradename: USP
• refractive index: n20/D 1.47 (lit.)
• bp: 202 °C (lit.), 81-82 °C/10 mmHg (lit.)
• mp: −24 °C (lit.)
• density: 1.028 g/mL at 25 °C (lit.)
• application(s): USP Biologics; pharmaceutical (small molecule); pharmaceutical
• format: neat
• SMILES string: CN1CCCC1=O
• InChI: 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
• InChI key: SECXISVLQFMRJM-UHFFFAOYSA-N

Descripción

General description

Find answers to frequently asked questions on USP products in USP FAQs.

Methylpyrrolidone is a highly polar solvent used in biologics formulations, particularly for drugs that require solubilization of hydrophobic compounds. It facilitates the delivery and stability of poorly soluble biologics by enhancing their dissolution properties. NMP is widely used in drug delivery systems, contributing to more efficient therapeutic delivery.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methylpyrrolidone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

This product is part of USP Biologics Program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de advertencia: Danger
• Códigos de peligro: H315,H319,H335,H360D
• Indicaciones de precaución: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 1
• Punto de inflamación (°F): 195.8 °F - Pensky-Martens closed cup
• Punto de inflamación (°C): 91 °C - Pensky-Martens closed cup