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Supelco

Astec® CHIROBIOTIC® R Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 4.6 mm, HPLC Column

Sinónimos:

Chiral Recognition HPLC Column

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About This Item

Código UNSPSC:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Astec® Chirobiotic® R Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm

Materiales

stainless steel column

descripción

HPLC column

Línea del producto

Astec®

envase

pkg of 1 ea

fabricante / nombre comercial

Astec®

Parámetros

0-45 °C temperature
241 bar pressure (3500 psi)

técnicas

HPLC: suitable
LC/MS: suitable

L × D.I.

25 cm × 4.6 mm

matriz

high-purity silica gel particle platform
fully porous particle

grupo activo de la matriz

ristocetin A glycopeptide phase

tamaño de partícula

5 μm

tamaño de poro

100 Å

operating pH range

3.5-6.8

técnica de separación

chiral

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Descripción general

CHIROBIOTIC® R, based on the ristocetin A glycopeptide covalently bonded to high purity silica particles, has shown particular applicability to enantiomers of anionic compounds. Selectivity on CHIROBIOTIC® R strongly correlates to the organic modifier, favoring the alcohol-type mobile phases by a large margin.

  • Bonded phase: Ristocetin A
  • Operating pH range: 3.5 - 6.8
  • Particle diameter: 5, 10 or 16 μm
  • Pore size: 100 Å

CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature

Aplicación


  • Sensitive Determination of Lactic Acid Isomers: The Astec® CHIROBIOTIC® R Chiral HPLC Column was crucial in a study by Henry H et al., where it facilitated the sensitive determination of D-lactic acid and L-lactic acid in urine using high-performance liquid chromatography-tandem mass spectrometry. This method is pivotal for clinical diagnostic applications, showcasing the column′s ability to resolve similar compounds that are challenging to differentiate by other means (Henry H et al., 2012).


  • Enantioseparation of Cyclopentanecarboxylic and Cyclohexanecarboxylic Acids: The column was also utilized by Berkecz R et al. to achieve high-performance liquid chromatographic enantioseparation of complex 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids. This application underscores the column′s versatility and efficacy in separating closely related chiral acids, essential for biochemical research and pharmaceutical product development (Berkecz R et al., 2009).

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Información legal

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

Aplicación

Referencia del producto
Descripción
Precios

G004409

HPLC Analysis of 2,3-Dihydroxy-3-Phenylpropionic Acid Enantiomers on CHIROBIOTIC R, application for HPLC

G004594

HPLC Analysis of Atrolactic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004667

HPLC Analysis of 2-Bromo-3-Methylbutyric Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004668

HPLC Analysis of N-(1-Phenylethyl)maleimide Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004669

HPLC Analysis of Dansyl-Glutamic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004670

HPLC Analysis of Dansyl-Leucine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004671

HPLC Analysis of Dansyl-Methionine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004672

HPLC Analysis of Dansyl-Norleucine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004673

HPLC Analysis of Dansyl-Phenylalanine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004675

HPLC Analysis of Dansyl-Valine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004676

HPLC Analysis of Alloisoleucine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004677

HPLC Analysis of FMOC-Aspartic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004678

HPLC Analysis of FMOC-Arginine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004679

HPLC Analysis of FMOC-Lysine Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

G004680

HPLC Analysis of 3-Phenyllactic Acid Enantiomers on Astec® CHIROBIOTIC® R, application for HPLC

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Certificados de análisis (COA)

Lot/Batch Number
292188-01
292164-01
292163-01
291970-01
291931-01

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Enzyme-catalyzed synthesis of (R)- and (S)-3-hydroxy-3-(10-alkyl-10H-phenothiazin-3-yl)propanoic acids
Brem, Jurgen, et al.
Tetrahedron Asymmetry, 21 (3), 365-373 (2010)
P Dehouck et al.
Journal of chromatography. A, 1010(1), 63-74 (2003-09-25)
Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in
Sébastien Canneaux et al.
The journal of physical chemistry. A, 114(34), 9270-9288 (2010-08-03)
The rate constants of the reactions of iodine atoms with H(2), H(2)O, HI, and OH have been estimated using 39, 21, 13, and 39 different levels of theory, respectively, and have been compared to the available literature values over the
Diane E Halliwell et al.
Scientific data, 4, 170084-170084 (2017-07-12)
Using a scanning near-field optical microscope coupled to an infrared free electron laser (SNOM-IR-FEL) in low-resolution transmission mode, we collected chemical data from whole cervical cells obtained from 5 pre-menopausal, non-pregnant women of reproductive age, and cytologically classified as normal
H Henry et al.
Biomedical chromatography : BMC, 26(4), 425-428 (2011-08-16)
D-lactic acid in urine originates mainly from bacterial production in the intestinal tract. Increased D-lactate excretion as observed in patients affected by short bowel syndrome or necrotizing enterocolitis reflects D-lactic overproduction. Therefore, there is a need for a reliable and
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Protocolos

Determination of L- and D-Lactic Acid Enantiomers by HPLC/MS/MS

Rapid, simple, reproducible chiral separation and quantification of L- and D-lactic acid enantiomers using Supelco’s Astec CHIROBIOTIC® R chiral column and tandem MS.

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

Chromatograms

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