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Merck

T9429

Sigma-Aldrich

Anti-Transforming Growth Factor-β, pan antibody produced in rabbit

IgG fraction of antiserum, lyophilized powder

Sinónimos:

Anti-TGF-β, pan

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About This Item

Número MDL:
Código UNSPSC:
51111800
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

lyophilized powder

reactividad de especies

amphibian, human, pig

técnicas

microarray: suitable
neutralization: suitable
western blot: suitable

Nº de acceso UniProt

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

Especificidad

The antibody will neutralize the biological activity of human TGF-β1, porcine TGF-β1.2, porcine TGF-β2, human TGF-β3, and amphibian TGF-β5.

Inmunógeno

mixture of recombinant human TGF-β1, porcine TGF-β1.2, porcine TGF-β2, and recombinant amphibian TGF-β5.

Acciones bioquímicas o fisiológicas

The effect of intraperitoneal injection of Anti-Transforming Growth Factor-β, pan antibody produced in rabbit in monocrotaline-induced pulmonary hypertension was studied in rat model.

Forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Nota de preparación

Purified using protein A.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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Ya-Wen Hsiao et al.
Journal of immunology (Baltimore, Md. : 1950), 172(3), 1508-1514 (2004-01-22)
IL-6 is a multifunctional cytokine that regulates cell growth, differentiation, and cell survival. Many tumor cells produce TGF-beta1, which allows them to evade CTL-mediated immune responses. IL-6 antagonizes TGF-beta1 inhibition of CD3 cell activation. However, whether IL-6 restores NK activity
Steven M Driever et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372(1730) (2017-08-16)
To meet the growing demand for food, substantial improvements in yields are needed. This is particularly the case for wheat, where global yield has stagnated in recent years. Increasing photosynthesis has been identified as a primary target to achieve yield
Samuel P Hoile et al.
PloS one, 9(10), e109896-e109896 (2014-10-21)
Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation of
Aikaterini J Megalou et al.
International journal of clinical and experimental medicine, 3(4), 332-340 (2010-11-13)
The role of transforming growth factor-β in the pathogenesis of pulmonary arterial hypertension is unclear. We examined the effects of T9429, an antibody against transforming growth factor-β receptors, on hemodynamic, histological and functional parameters in the rat model of monocrotaline-induced
Tal Fisher et al.
Cell reports, 39(11), 110954-110954 (2022-06-08)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA translation. However, the diverse molecular mechanisms employed by nsp1 as well as its functional importance are

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