Saltar al contenido
Merck

Documentos clave

Ver Toda la documentación

Saltar a

T4540

Triacsin C

From Streptomyces sp., long-chain fatty acyl CoA synthetase inhibitor, powder

Sinónimos:

2,4,7-Undecatrienal nitrosohydrazone, WS1228A

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

Cambiar Vistas
A ustedes/SKUDisponibilidadPrecio
1 mg
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
913,00 €

Acerca de este artículo

Fórmula empírica (notación de Hill):
C11H17N3O
Número CAS:
76896-80-5
Peso molecular:
207.27
UNSPSC Code:
51111800
PubChem Substance ID:
24900214
NACRES:
NA.77
MDL number:
MFCD00798237
Form:
powder

913,00 €

Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
​
Solicita un pedido personalizado
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle

Nombre del producto

Triacsin C from Streptomyces sp.,

biological source

Streptomyces sp.

Quality Segment

200

form

powder

solubility

methanol: soluble 4.90-5.10 mg/mL, clear (Pale yellow to yellow), methanol: soluble 4.90-5.10 mg/mL, clear, pale yellow to yellow

mode of action

enzyme | inhibits

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCC\C=C\C\C=C\C=C\C=N\NN=O

InChI

1S/C11H17N3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15/h4-5,7-11H,2-3,6H2,1H3,(H,13,15)/b5-4+,8-7+,10-9+,12-11+

InChI key

NKTGCVUIESDXPU-YLEPRARLSA-N

General description

Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus.

Application

Triacsin C was found to induce maturation in mouse and Xenopus oocytes in the absence of long-chain acyl-CoA synthetase. Triacsin C can also block palmitoylation of the G-protein alpha S subunit6. Furthermore, triacsin C can stabilize1-oleoyl-2-acetyl-sn-glycerol (OAG) and enhance perilipin 3 recruitment to the endoplasmic reticulum (ER) in mouse cells7.

Biochem/physiol Actions

Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.

Preparation Note

Triacsin C is soluble in methanol at 4.90 - 5.10 mg/ml and yields a clear, pale yellow to yellow solution.

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 1

Este artículo
T7765M0440T8902
Triacsin C from Streptomyces sp.

Sigma-Aldrich

T4540

Triacsin C from Streptomyces sp.

Tunicamycin from Streptomyces sp.

Sigma-Aldrich

T7765

Tunicamycin from Streptomyces sp.

Mitomicina C from Streptomyces caespitosus meets USP testing specifications

Sigma-Aldrich

M0440

Mitomicina C from Streptomyces caespitosus

Thiostrepton from Streptomyces azureus ≥90% (HPLC)

Sigma-Aldrich

T8902

Thiostrepton from Streptomyces azureus

form

powder

form

-

form

-

form

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

methanol: soluble 4.90-5.10 mg/mL, clear (Pale yellow to yellow), methanol: soluble 4.90-5.10 mg/mL, clear, pale yellow to yellow

solubility

95% ethanol: soluble 1 mg/mL, clear to faintly hazy, THF: soluble <1 mg/mL, dioxane: soluble <1 mg/mL, DMF: soluble >10 mg/mL, pyridine: >10 mg/mL, DMSO: soluble 4.9-5.1 mg/mL, clear to slightly hazy, colorless to yellow, methanol: slightly soluble 4.9-5.1 mg/mL, methanol: soluble 4.9-5.1 mg/mL, clear to slightly hazy, colorless to yellow, acetone: insoluble, aqueous base: insoluble, chloroform: insoluble, ethyl acetate: insoluble

solubility

H2O: 40 mg/mL, clear to very slightly hazy, colorless, H2O: soluble

solubility

acetic acid: soluble 25 mg/mL, clear to hazy, yellow to brownish-yellow

shipped in

wet ice

shipped in

-

shipped in

-

shipped in

-

mode of action

enzyme | inhibits

mode of action

protein synthesis | interferes

mode of action

DNA synthesis | interferes

mode of action

protein synthesis | interferes

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documentos section.

Si necesita más asistencia, póngase en contacto con Atención al cliente

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Preguntas

Revisiones

Sin puntuación

Filtros activos