T1783

Tobramycin sulfate salt

aminoglycoside antibiotic

• Sinónimos: Nebramycin Factor 6 sulfate
• Fórmula empírica (notación de Hill): C₁₈H₃₇N₅O₉ · xH₂SO₄
• Peso molecular: 467.51 (free base basis)
• Número MDL: MFCD00133864
• Código UNSPSC: 51281677
• ID de la sustancia en PubChem: 329826686
• NACRES: NA.85

Propiedades

• origen biológico: Streptomyces tenebrarius
• formulario: powder
• potencia: 634-739 μg per mg
• condiciones de almacenamiento: (Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
• color: white to off-white
• solubilidad: H₂O: soluble 50 mg/mL
• espectro de actividad antibiótica: Gram-negative bacteria
• Modo de acción: protein synthesis | interferes
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1
• Clave InChI: ZEUUPKVZFKBXPW-TWDWGCDDSA-N

Descripción

Descripción general

Chemical structure: aminoglycoside

Aplicación

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections. Product T1783 has been used to study antibiotic resistance.

Acciones bioquímicas o fisiológicas

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA.

Tobramycin sulfate is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

Envase

100MG,500MG

Precaución

Hygroscopic

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H312 + H332,H360
• Consejos de prudencia: P202 - P261 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Clasificaciones de peligro: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges