T124

Thapsigargin

• Fórmula empírica (notación de Hill): C₃₄H₅₀O₁₂
• Número CAS: 67526-95-8
• Peso molecular: 650.75
• UNSPSC Code: 12352204
• MDL number: MFCD00083511

Propiedades

• storage temp.: −20°C
• SMILES string: [H][C@@]12C([C@H](OC([C@]3(O)C)=O)[C@]3(O)[C@@H](OC(CCC)=O)C[C@]2(C)OC(C)=O)=C(C)[C@H](OC(/C(C)=C(C)/[H])=O)[C@H]1OC(CCCCCCC)=O
• InChI: 1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
• InChI key: IXFPJGBNCFXKPI-FSIHEZPISA-N

Descripción

Biochem/physiol Actions

Potent, cell-permeable, IP₃-independent intracellular calcium releaser.

Thapsigargin is a potent, cell-permeable, IP₃-independent intracellular calcium release. It blocks the transient increase in intracellular Ca²⁺ induced by angiostatin and endostatin. It also induces apoptosis by disrupting intracellular free Ca²⁺ levels and is incorporated into chemotherapeutic prodrug formulations.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H334,H335
• pcodes: P261 - P264 - P271 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves