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Merck

T0951

Sigma-Aldrich

Anti-Tet Repressor (TETR) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Tetracycline Repressor Protein

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen ~22 kDa by calculation

reactividad de especies

human

técnicas

indirect ELISA: suitable
western blot: 1:1,000

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Categorías relacionadas

Descripción general

Tet Repressor (TETR) is homodimer comprising a C-terminal helix-turn-helix motif (HTH) and N-terminal DNA-binding domain,. It also has a C-terminal tetracycline-binding and dimerization (TBD) domain.

Inmunógeno

Anti-Tet Repressor (TETR) reacts with amino acid residues 31-49 (AQKLGVEQPTLYWHVKNKR) of 22 kDa Tet repressor protein

Aplicación

Anti-Tet Repressor (TETR) antibody produced in rabbit has been used in western blotting.

Acciones bioquímicas o fisiológicas

The Tet system is employed in conditional gene expression studies in eukaryotic cells. TetR ( can be used for such applications in some organisms without further modifications. In mammals and in a large variety of other organisms, however, eukaryotic transcriptional activator or repressor domains are fused to TetR to turn it into an efficient regulator. TetR interaction with antibiotic tetracyclin decreases its binding affinity to DNA.

Forma física

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressor
Reichheld SE, et al.
Proceedings of the National Academy of Sciences of the USA, 106(52), 22263-22268 (2009)
The application of Tet repressor in prokaryotic gene regulation and expression
Bertram R and Hillen W
Microbial Biotechnology, 1(1), 2-16 (2008)
The TetR family of transcriptional repressors
Ramos JL, et al.
Microbiology and Molecular Biology Reviews, 69(2), 326-356 (2005)
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells
Zhang X, et al.
Nature Cell Biology, 13(9), 1092-1092 (2011)
Alicia Broto et al.
Nature communications, 13(1), 1910-1910 (2022-04-09)
Mycoplasmas have exceptionally streamlined genomes and are strongly adapted to their many hosts, which provide them with essential nutrients. Owing to their relative genomic simplicity, Mycoplasmas have been used to develop chassis for biotechnological applications. However, the dearth of robust

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