SRP6399

IL-2 R beta/CD122 human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Sinónimos: IL2RB, P70-75, RP5-1170K4.6
• Código UNSPSC: 12352202

Propiedades

• origen biológico: human
• recombinante: expressed in HEK 293 cells
• etiqueta: 6-His tagged (C-terminus)
• Análisis: ≥90% (SDS-PAGE)
• formulario: lyophilized
• mol peso: calculated mol wt 25.4 kDa; observed mol wt 40 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 27 is the predicted N-terminus.)
• envase: pkg of 10 μg
• impurezas: <1 EU/μg endotoxin (LAL test)
• Nº de acceso UniProt: P14784
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... IL2RB(3560)

Descripción

Descripción general

Interleukin-2 receptor (IL-2R)/ cluster of differentiation 122 (CD122) is a heterotrimeric protein, encoded by the gene mapped to human chromosome 22q12.3. The encoded protein is expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α subunit is involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. IL2R β is a member of the type I cytokine receptor family.

Aplicación

Interleukin 2 receptor subunit β (IL2RB)/cluster of differentiation 122 (CD122) human has been used to study the effect of this cytokine on the expression of Klf15 in neurons.

Acciones bioquímicas o fisiológicas

Interleukin 2 receptor subunit β (IL2RB) is involved in signal transduction via its ligand interleukin-2. It is also implicated in inflammation. Cluster of differentiation 122 (CD122) is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

Forma física

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable