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Key Documents

SRP6263

Sigma-Aldrich

PLGF/PIGF2/PGF human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinónimos:

PGFL, SHGC-10760

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

recombinante

expressed in HEK 293 cells

etiqueta

6-His tagged (C-terminus)

Análisis

≥95% (SDS-PAGE)

formulario

lyophilized powder

mol peso

calculated mol wt 20.2 kDa
observed mol wt 28-33 kDa (DTT-reduced. Protein migrates due to glycosylation. Arg 29 is the predicted N-terminus.)

envase

pkg of 10 μg

impurezas

<1 EU/μg endotoxin (LAL test)

Nº de acceso UniProt

P49763

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

human ... PLGF(5228)

Descripción general

Placental growth factor (PLGF) exists in two isoforms namely PLGF1 and PLGF2. This protein is a homodimeric glycoprotein with molecular weight of 46–50kDa and is a member of the VEGF (vascular endothelial growth factor) subfamily. PLGF is encoded by the gene mapped to human chromosome 14q24-q31 regions. PLGF is expressed mainly in the placental trophoblast during pregnancy and is also present in various other tissues such as the villous trophoblast.

Acciones bioquímicas o fisiológicas

PLGF might enhance the production of peripheral blood mononuclear cell-vascular endothelial growth factor (PBMC-VEGF). Consequently, PlGF might facilitate VEGF production in the inflammatory joint. Soluble fms related tyrosine kinase 1 (Flt-1), which is considered to be an anti-angiogenic factor interacts with and inhibit the activity of PLGF. Therefore, PLGF level is lowered and the Flt-1 level is increased in placental tissue of women with pre-eclampsia (PE). PLGF is associated with the pathogenesis of rheumatoid arthritis (RA) and various other arthropathies. PLGF acts as a ligand for VEGFR-1 and is implicated in various physiological functions such as tumor angiogenesis, wound healing and hematopoietic progenitors recruitment.

Forma física

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders.
Khalil A
PLoS ONE, 3(7), e2766-e2766 (2008)
Role of placenta growth factor (PIGF) in human extravillous trophoblast proliferation, migration and invasiveness.
Athanassiades A and Lala PK
Placenta, 19(7), 465-473 (1998)
PlGF blockade does not inhibit angiogenesis during primary tumor growth.
Bais C
Cell, 141(1), 166-177 (2010)
Placenta growth factor (PlGF) induces vascular endothelial growth factor (VEGF) secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid.
Bottomley MJ
Clinical and Experimental Immunology, 119(1), 182-188 (2000)
Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 and 14q24-q31 regions, respectively.
M G Mattei et al.
Genomics, 32(1), 168-169 (1996-02-15)

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