SRP5222
MSK2, active, GST tagged from mouse
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
RPS6KA4, RSK-B, RSKB
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
recombinante
expressed in baculovirus infected Sf9 cells
Línea del producto
PRECISIO® Kinase
Análisis
≥70% (SDS-PAGE)
formulario
buffered aqueous glycerol solution
actividad específica
7.5-10.4 nmol/min·mg
mol peso
~114 kDa
Nº de acceso NCBI
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
mouse ... Rps6ka4(56613)
Descripción general
MSK2 (mitogen- and stress-activated protein kinase-2) is a member of the serine/threonine kinase family that contains two non-identical kinase catalytic domains. MSK2 is also known as ribosomal protein S6 kinase polypeptide 4 (RPS6KA4), that is activated by the mitogen-activated protein kinases- extracellular signal-regulated kinases 1 and 2 (ERK1 and -2) and p38.
Acciones bioquímicas o fisiológicas
MSK2 (mitogen- and stress-activated protein kinase-2) phosphorylates various substrates like cyclic AMP-responsive element-binding protein 1 (CREB1) and the proto-oncogene c-fos. It is a histone-modifying enzyme and a mitogenic factor. The protein is involved in the G1-phase of the cell cycle and has a role in apoptosis. It also modulates the functions of various transcription factors.
Forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparación
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Información legal
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
Roux PP and Blenis J
Microbiology and Molecular Biology Reviews, 68(2), 320-344 (2004)
Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.
Karelina K
Neuroscience, 285, 292-302 (2015)
Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
Lang E
Scientific Reports, 5, 17316-17316 (2015)
Comparison of epigenetic mediator expression and function in mouse and human embryonic blastomeres.
Chavez SL, McElroy SL, Bossert NL, et al.
Human Molecular Genetics, 23(18), 4970-4984 (2014)
B Pierrat et al.
The Journal of biological chemistry, 273(45), 29661-29671 (1998-10-29)
A novel ribosomal S6 kinase (RSK) family member, RSK-B, was identified in a p38alphaMAPK-baited intracellular interaction screen. RSK-B presents two catalytic domains typical for the RSK family. The protein kinase C-like N-terminal and the calcium/calmodulin kinase-like C-terminal domains both contain
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