SRP3331
G-CSF from mouse
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinónimos:
CSF-3, MGI-1G, pluripoietin
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
mouse
recombinante
expressed in E. coli
Análisis
≥98% (HPLC)
≥98% (SDS-PAGE)
formulario
lyophilized
potencia
≤0.05 ng/mL
mol peso
19.0 kDa
envase
pkg of 10 μg
impurezas
endotoxin, tested
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... CSF3(12985)
Descripción general
Colony stimulating factor 3 (CSF-3) or granulocyte colony stimulating factor (G-CSF) is a hematopoietic growth factor. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. Human and murine G-CSF is cross-species reactive. Recombinant murine G-CSF is a 19.0kDa protein consisting of 179 amino acid residues.
Acciones bioquímicas o fisiológicas
Colony stimulating factor 3 (CSF-3) or granulocyte colony stimulating factor (G-CSF) stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It also has a role in macrophage generation and may be involved in immune modulation. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation.
Forma física
Lyophilized from 10 mM Sodium Citrate, pH 4.0.
Reconstitución
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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The importance of the granulocyte-colony stimulating factor in oncology.
Cetean S
Clujul Medical (1957), 88(4), 468-472 (2015)
H S Lu et al.
Archives of biochemistry and biophysics, 268(1), 81-92 (1989-01-01)
Molecular characteristics and secondary structures of recombinant methionyl human granulocyte colony stimulating factor produced by genetically engineered Escherichia coli are described. Limited radiolabeling of the protein with tritiated iodoacetate and determination of the labeled residue revealed that this recombinant protein
Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.
Meshkibaf S
Cytokine, 78, 69-78 (2016)
Gerald Wirnsberger et al.
Nature genetics, 46(9), 1028-1033 (2014-08-19)
Neutrophils are key innate immune effector cells that are essential to fighting bacterial and fungal pathogens. Here we report that mice carrying a hematopoietic lineage-specific deletion of Jagn1 (encoding Jagunal homolog 1) cannot mount an efficient neutrophil-dependent immune response to
Yaron Vagima et al.
PLoS pathogens, 11(5), e1004893-e1004893 (2015-05-15)
Pneumonic plague is a fatal disease caused by Yersinia pestis that is associated with a delayed immune response in the lungs. Because neutrophils are the first immune cells recruited to sites of infection, we investigated the mechanisms responsible for their
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