SRP3018
Beta -NGF human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Sinónimos:
beta-Nerve Growth Factor
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Análisis
≥98% (HPLC)
≥98% (SDS-PAGE)
formulario
lyophilized
potencia
<1.0 ng/mL ED50
mol peso
13.5 kDa
envase
pkg of 20 μg
técnicas
cell culture | mammalian: suitable
impurezas
<0.1 EU/μg endotoxin, tested
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... NFG(4803)
Descripción general
NGFβ (nerve growth factor β) is a protein involved in signal transduction, and expressed by multiple tissues such as placenta, urothelium and bladder smooth muscle cells. It was discovered by Levi-Montalcini, and is the founding member of the neurotrophin and belongs to the NGF family.
Aplicación
NGFβ (nerve growth factor β) has been used for the treatment of normal human bronchial epithelial cells (NHBE), to determine its influence on ion transport in the presence of amiloride, NPPB, and ouabain. It has also been used for the apical incubation with MKHS (modified Krebs-Henseleit solution) in cells to determine its stability and concentration post- prolonged incubation periods in MKHS.
Acciones bioquímicas o fisiológicas
NGFβ (nerve growth factor β) is essential for the differentiation and survival of neurons. It also plays a key role in the development and maintenance of nervous system. It is also involved in angiogenesis, and facilitates tumorigenesis such as, oral, breast and prostate cancers. It has potential as marker for the diagnosis of interstitial cystitis/painful bladder syndrome (IC/PBS) and overactive bladder (OAB), and might also aid in determining the therapy for the same. It might be involved in changes in placental function, as NGFβ signaling is influenced by antenatal depression and selective serotonin reuptake inhibitor (SSRI) treatment.
Secuencia
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR
Forma física
Lyophilized with no additives.
Reconstitución
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a Stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells.
Shimko MJ, et al.
Physiological Reports, 2(7) (2014)
Li Lin et al.
Molecules (Basel, Switzerland), 24(10) (2019-05-28)
Two optical isomers, +/- gelsemine (1, 2), together with one known compound were isolated from the whole plant of G. elegans. The structures of the separated constituents were elucidated on 1D and 2D (1H-1H COSY, HMBC, HSQC) NMR spectroscopy and
Over-expression of nerve growth factor-? in human cholangiocarcinoma QBC939 cells promote tumor progression.
Yue XJ, et al.
PLoS ONE, 8(4) (2013)
The effect of antenatal depression and selective serotonin reuptake inhibitor treatment on nerve growth factor signaling in human placenta.
Kaihola H, et al.
PLoS ONE, 10(1) (2015)
Urinary nerve growth factor could be a biomarker for interstitial cystitis/painful bladder syndrome: a meta-analysis.
Qu HC, et al.
PLoS ONE, 9(9) (2014)
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