SRP2133
LXR, α isoform, N-terminal region (1-182), GST tagged β human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Sinónimos:
LXR-a, LXRA, RLD-1
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.26
origen biológico
human
recombinante
expressed in E. coli
Análisis
≥80% (SDS-PAGE)
formulario
frozen liquid
mol peso
~47.5 kDa
envase
pkg of 10 μg
concentración
300 μg/mL
color
clear colorless
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... NR1H3(10062)
Acciones bioquímicas o fisiológicas
Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRα and LXRβ. LXRα is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRβ expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXRα is thought to play a major role in the control of cholesterol catabolism by stimulating the expression of cholesterol 7-α-hydroxylase (CYP7A1), the rate limiting enzyme of bile acid synthesis.
Forma física
Clear and colorless frozen liquid solution
Nota de preparación
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
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D J Peet et al.
Current opinion in genetics & development, 8(5), 571-575 (1998-10-31)
The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has
R Apfel et al.
Molecular and cellular biology, 14(10), 7025-7035 (1994-10-01)
The steroid/hormone nuclear receptor superfamily comprises several subfamilies of receptors that interact with overlapping DNA sequences and/or related ligands. The thyroid/retinoid hormone receptor subfamily has recently attracted much interest because of the complex network of its receptor interactions. The retinoid
P J Willy et al.
Genes & development, 9(9), 1033-1045 (1995-05-01)
We have identified a new retinoid response pathway through which 9-cis retinoic acid (9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear receptor superfamily. LXR alpha shows a specific pattern of expression in visceral organs
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