SRP2067

CAR, ligand binding domain (101-348) human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

• Sinónimos: CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• Código UNSPSC: 12352202
• NACRES: NA.26

Propiedades

• origen biológico: human
• recombinante: expressed in E. coli
• Análisis: ≥85% (SDS-PAGE)
• formulario: frozen liquid
• mol peso: ~30 kDa
• envase: pkg of 10 μg
• condiciones de almacenamiento: avoid repeated freeze/thaw cycles
• concentración: 500 μg/mL
• color: clear; colorless
• Nº de acceso NCBI: NM_005122
• Nº de acceso UniProt: Q14994
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... NR1I3(9970)

Descripción

Acciones bioquímicas o fisiológicas

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by `phenobarbitol-like` compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable