SRP2042

LXRα-ligand binding domain (215-667) human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• Sinónimos: LXR-a, LXRA, RLD-1
• Código UNSPSC: 12352200
• NACRES: NA.26

Propiedades

• origen biológico: human
• recombinante: expressed in E. coli
• Análisis: ≥70% (SDS-PAGE)
• formulario: frozen liquid
• mol peso: ~30.6 kDa
• envase: pkg of 10 μg
• concentración: 300 μg/mL
• color: clear colorless
• Nº de acceso NCBI: NM_005693
• Nº de acceso UniProt: Q13133
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• Información sobre el gen: human ... NR1H3(10062)

Descripción

Acciones bioquímicas o fisiológicas

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXRa is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR β expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). The ligand binding domain (LBD) of LXR determines ligand specificity and mediates the trans-activation function of the receptor.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable