SRP0410
ALOX15 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)
Sinónimos:
15LOX-1, arachidonate 15-lipoxygenase
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in baculovirus infected Sf9 cells
Análisis
≥60% (SDS-PAGE)
formulario
aqueous solution
mol peso
75 kDa
envase
pkg of 20 μg
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... ALOX15(246)
Descripción general
The gene ALOX15 (arachidonate 15-lipoxygenase) is mapped to human chromosome 17p13. It is mainly present in the epithelial cells in the upper airways, reticulocytes, eosinophils and macrophages. ALOX15 belongs to the dioxygenases family. It is an IL-4 (interleukin 4)/IL-13 target gene.
ALOX-15, also known as 15LOX-1, ω-6 lipoxygenase, or arachidonate 15-lipoxygenase (GenBank Accession No. NM_001140) amino acids 2- 662 (end) with N-terminal FLAG-tag, MW = 75kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
ALOX-15, also known as 15LOX-1, ω-6 lipoxygenase, or arachidonate 15-lipoxygenase (GenBank Accession No. NM_001140) amino acids 2- 662 (end) with N-terminal FLAG-tag, MW = 75kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
Aplicación
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Acciones bioquímicas o fisiológicas
ALOX15 (arachidonate 15-lipoxygenase) is involved in homeostatic as well as pathological responses. ALOX15 is responsible for the oxidation of unsaturated fatty acids (at the 15 position) to active hydroperoxy and epoxy metabolites. It is also responsible for the conversion of linoleic acid to anti-tumor 13-S-hydroxyoctadecadienoic acid. ALOX15 is required for IL-4 (interleukin-4)/IL-13-mediated macrophage polarization. In mice, it is a negative regulator of bone mineral density. It is also involved in fatty acid metabolism. It controls MAPK (mitogen activated protein kinase) signaling in human airway epithelial cells using phosphatidylethanolamine-binding protein.
Forma física
Formulated in Tris-Buffered Saline (TBS), pH 7.4, containing 1 mM Fe(NH4)2(SO4)2.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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12/15 Lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models.
Chang J, et al.
Oncotarget, 6, 2879-2879 (2015)
Polymorphisms in inflammation associated genes ALOX15 and IL-6 are associated with bone properties in young women and fracture in elderly.
Herlin M, et al.
Bone, 79, 105-105 (2015)
Wen G Jiang et al.
Prostaglandins, leukotrienes, and essential fatty acids, 74(4), 235-245 (2006-03-25)
15-lipoxygenase (15-LOX) belongs to the structurally and functionally related nonheme iron dioxygenases family. It has two isoforms, type-1 (leukocyte type) and type-2 (epidermis type) and converts arachidonic acid to eicosanoids including the anti-cancer 13-HODE. In the current study, we investigate
15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.
Zhao J, et al.
Proceedings of the National Academy of Sciences of the USA, 108, 14246-14246 (2011)
Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity.
Andersson E, et al.
Biochimica et Biophysica Acta, 1761, 1498-1498 (2006)
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