SML3770

BMS-466442

≥98% (HPLC)

• Sinónimos: (S)-Methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-benzyloxy-5-methoxy-1H-indole-2-carboxamido)propanoate, BMS 466442, BMS466442, N-[[5-Methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-L-histidine methyl ester
• Fórmula empírica (notación de Hill): C₃₁H₃₀N₄O₅
• Número CAS: 1598424-76-0
• Peso molecular: 538.59
• UNSPSC Code: 12352200
• MDL number: MFCD35060520
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: COC([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C(NC3=C4)=CC3=CC(OC)=C4OCC5=CC=CC=C5)=O)=O
• InChI key: UUCAHZCMRZOTNF-MHZLTWQESA-N

Descripción

Biochem/physiol Actions

Potent and selective alanine serine cysteine transporter-1 (ASC-1; SLC7A10) inhibitor that effectively blocks ASC-1-mediated cellular D-Ser uptake.



BMS-466442 is a selective alanine serine cysteine transporter-1 (ASC-1) inhibitor (D-Ser uptake IC50 = 36.8 nM and 19.7 nM using HEK human ASC-1 transfectants or primary rat embryonic cortical cultures, respectively) with good selectivity over >40 other targets, including LAT-2 or ASCT-2 (IC50 >10 μM).

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable