SML3723

JNJ-26854165

≥98% (HPLC)

• Sinónimos: 1-N-[2-(1H-Indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, JNJ 1, JNJ 26854165, N1-[2-(1H-Indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine, Serdemetan
• Fórmula empírica (notación de Hill): C₂₁H₂₀N₄
• Número CAS: 881202-45-5
• Peso molecular: 328.41
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD16620518
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(c(c1)CCNc3ccc(cc3)Nc4ccncc4)cccc2
• InChI key: CEGSUKYESLWKJP-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Inhibitor of the E3 ligase human double minute-2 (HDM2); cholesterol transport inhibitor

JNJ-26854165 (serdemetan) is an inhibitor of the E3 ligase human double minute-2 (HDM2) that inhibits cell proliferation and induces apoptosis in models of acute myeloid and lymphoid leukemias, and solid tumors. Also JNJ-26854165 inhibits cholesterol transport. JNJ-26854165 appears to stimulate cholesterol regulatory genes, but simultaneously inhibits cholesterol transport.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable