SML3456

LUF7244

≥98% (HPLC)

• Sinónimos: 2-​[4-​(3-​Chlorobenzoyl)​phenoxy]​-​N-​3-​pyridinyl-acetamide
• Fórmula empírica (notación de Hill): C₂₀H₁₅ClN₂O₃
• Número CAS: 1821638-43-0
• Peso molecular: 366.80
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C(NC1=CC=CN=C1)COC2=CC=C(C=C2)C(C3=CC=CC(Cl)=C3)=O
• InChI key: KKKJYDOHVKIIQP-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

LUF7244 is a potent and selective voltage-gated potassium 11.1 (Kv11.1) channels negative allosteric modulator/activator that inhibits early afterdepolarizations in vitro. It decreases the affinity of Kv11.1 for cisapride, astemizole, dofetilide and sertindole. LUF7244 averts dofetilide‐induced torsades de pointes arrhythmias in dogs with chronic atrioventricular block. LUF7244 in combination with dofetilide rescues both congenital and acquired Kv11.1 trafficking defects and produces functional Kv11.1 current in trafficking defective G601S-Kv11.1 cells.

Potent and selective voltage-gated potassium 11.1 (Kv11.1) channels negative allosteric modulator/activator that inhibits early afterdepolarizations

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable