SML3420

KY-226

≥97% (HPLC)

• Sinónimos: 4-((Biphenyl-4-ylmethylthio)methyl)-N-(hexylsulfonyl)benzamide, 4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide, 4-[[([1,1′-Biphenyl]-4-ylmethyl)thio]methyl]-N-(hexylsulfonyl)benzamide
• Fórmula empírica (notación de Hill): C₂₇H₃₁NO₃S₂
• Número CAS: 1621673-53-7
• Peso molecular: 481.67
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD32263946
• Assay: ≥97% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1
• InChI: 1S/C27H31NO3S2/c1-2-3-4-8-19-33(30,31)28-27(29)26-17-13-23(14-18-26)21-32-20-22-11-15-25(16-12-22)24-9-6-5-7-10-24/h5-7,9-18H,2-4,8,19-21H2,1H3,(H,28,29)
• InChI key: MKXMABKUVSOEJF-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

KY-226 is an orally bioavailable, potent and selective allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) that does not function as a PPARg agonist. KY-226 exhibits anti-diabetic, anti-obesity effects by enhancement of insulin and leptin signaling in mice. It appears that KY-226 exerts neuroprotective effects through restoration of phosphorylation of Akt and FoxO1. Thus, it protects BBB integrity by restoration of tight junction (TJ) proteins in mice.

Orally bioavailable, potent and selective allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable