SML0849

GKA50

≥98% (HPLC)

• Sinónimos: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic acid
• Fórmula empírica (notación de Hill): C₂₆H₂₈N₂O₆
• Número CAS: 851884-87-2
• Peso molecular: 464.51
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: N(c3ncc(cc3)C(=O)O)C(=O)c1cc(cc(c1)O[C@H](Cc2ccccc2)C)O[C@H](COC)C
• InChI: 1S/C26H28N2O6/c1-17(11-19-7-5-4-6-8-19)33-22-12-21(13-23(14-22)34-18(2)16-32-3)25(29)28-24-10-9-20(15-27-24)26(30)31/h4-10,12-15,17-18H,11,16H2,1-3H3,(H,30,31)(H,27,28,29)/t17-,18-/m0/s1
• InChI key: OCBMECSFDVUYQN-ROUUACIJSA-N

Descripción

Biochem/physiol Actions

GKA50 is a specific activator of glucokinase (EC₅₀ = 0.03 μM). In mouse MIN6 insulin-secreting cells and rat pancreatic islet cells, GKA50 elicits a leftward shift in response to sub-maximal glucose concentrations as measured by insulin secretion and elevation of intracellular calcium levels.

GKA50 is a specific activator of glucokinase.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302,H413
• Indicaciones de precaución: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable