SML0313

Pimelic Diphenylamide 106

≥98% (HPLC)

• Sinónimos: Compound 106, Inhibitor 106, N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide, RGFA 8, TC-H 106
• Fórmula empírica (notación de Hill): C₂₀H₂₅N₃O₂
• Número CAS: 937039-45-7
• Peso molecular: 339.43
• NACRES: NA.77
• PubChem Substance ID: 329825318
• UNSPSC Code: 12352200
• MDL number: MFCD17010287
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1
• InChI: 1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
• InChI key: WTKBRPXPNAKVEQ-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.

106 is a potent Class I HDAC inhibitor, demonstrating no activity against class II HDACs.

Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable