SML0263

PF-04217903

≥98% (HPLC)

• Sinónimos: 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol methanesulfonate (1:1)
• Fórmula empírica (notación de Hill): C₁₉H₁₆N₈O·CH₃SO₃H
• Número CAS: 956906-93-7
• Peso molecular: 468.49
• NACRES: NA.77
• PubChem Substance ID: 329825271
• UNSPSC Code: 12352200
• MDL number: MFCD17392584
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥5 mg/mL (warmed)
• storage temp.: 2-8°C
• SMILES string: CS(O)(=O)=O.OCCn1cc(cn1)-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2
• InChI: 1S/C19H16N8O.CH4O3S/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16;1-5(2,3)4/h1-5,8-10,12,28H,6-7,11H2;1H3,(H,2,3,4)
• InChI key: HBEMHKVWZJTVOC-UHFFFAOYSA-N
• Gene Information: human ... MET(4233)

Descripción

Application

PF-04217903 has been used as tyrosine-protein kinase Met (C-Met) selective inhibitor in Madin-Darby Canine kidney (MDCK) cells and NT2D1 non-seminoma cells.

Biochem/physiol Actions

PF-04217903 is a c-Met inhibitor.

PF-04217903 is a highly selective, potent inhibitor of the hepatocyte growth factor receptor c-Met. PF-04217903 inhibits endogenous, wild type c-Met in A549 human lung carcinoma cells with an IC₅₀ of 4.8 nM. The compund displays 1000-fold selectivity against a panel of 208 other kinases.

PF-04217903 is an ATP-competitive inhibitor. It elicits antiangiogenic functionality. PF-04217903 inhibits c-Met phosphorylation in xenograft models leading to partial tumor growth suppression.

Features and Benefits

This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable