SML0206

EAA-090

≥98% (HPLC)

• Sinónimos: P-[2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]-phosphonic acid, WAY-126090
• Fórmula empírica (notación de Hill): C₉H₁₃N₂O₅P
• Número de CAS: 144912-63-0
• Peso molecular: 260.18
• Número MDL: MFCD00912427
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825228

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: light yellow to yellow
• solubilidad: H₂O: ≥2 mg/mL
• emisor: Wyeth
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OP(O)(=O)CCN1CCCNC2=C1C(=O)C2=O
• InChI: 1S/C9H13N2O5P/c12-8-6-7(9(8)13)11(3-1-2-10-6)4-5-17(14,15)16/h10H,1-5H2,(H2,14,15,16)
• Clave InChI: BDABGOLMYNHHTR-UHFFFAOYSA-N

Descripción

Aplicación

EAA-090 was used to study the role of glutamate receptor-mediated signaling in the formation of filipodia and secondary dendrites in rat hippocampal neurons.

Acciones bioquímicas o fisiológicas

EAA-090 inhibits the binding of ligands to glutamate receptors and blocks NMDA-induced currents. It is neuroprotective against glutamate and ischemia-induced toxicity.

EAA-090 is a potent NMDA receptor antagonist with neuroprotective properties. In isoflurane-anesthetized dogs, EAA-090 reduces the minimum alveolar concentration (MAC) of isoflurane and increases systolic, mean, and diastolic arterial blood pressure.

Características y beneficios

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P301 + P310
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable