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Merck
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SML0045

Sigma-Aldrich

Salvianolic acid A hydrate

≥98% (HPLC)

Sinónimos:

Dan phenolic acid A hydrate

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About This Item

Fórmula empírica (notación de Hill):
C26H22O10 · xH2O
Número de CAS:
96574-01-5
Peso molecular:
494.45 (anhydrous basis)
Número MDL:
MFCD20527310
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825115
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

color

yellow

solubilidad

H2O: ≥19 mg/mL

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

cadena SMILES

O.OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2\C=C\c3ccc(O)c(O)c3

InChI

1S/C26H22O10.H2O/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15;/h1-12,23,27-31,33H,13H2,(H,34,35);1H2/b6-1+,10-5+;/t23-;/m1./s1

Clave InChI

XFUSRNNWIRPEDG-FYLUTCCGSA-N

Aplicación

Salvianolic acid A hydrate may be used in cell signaling studies.
Salvianolic acid A hydrate has been used as rosmarinic acid derivative for the inhibition of DNA polymerase e in human cell lines.

Acciones bioquímicas o fisiológicas

Salvianolic acid A acts as scavengers of reactive oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits matrix metalloproteinases and inflammation. It has cardioprotective effects as it suppresses apoptosis, reduces lipid peroxidation in damaged cardiac tissue and decreases the leakage of lactic acid dehydrogenase.
Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Tanshinone I ≥98% (HPLC)

Sigma-Aldrich

T5330

Tanshinone I

Rosmarinic acid ≥98% (HPLC), from Rosemarinus officinalis L.

Sigma-Aldrich

R4033

Rosmarinic acid

Rosmarinic acid primary reference standard

00390580

Rosmarinic acid

Jing Wang et al.
Folia neuropathologica, 59(1), 50-66 (2021-05-11)
More than 50 million people are affected by traumatic brain injury (TBI) each year around the world, and nearly half of the population worldwide will have one or more TBI(s) in their lifetime. And in 2017, more than 1.39 billion
Shou-Bao Wang et al.
Journal of Asian natural products research, 14(11), 1084-1092 (2012-10-31)
Epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH) have been associated with ischemic stroke. Salvianolic acid A (SAA) is proved to display potent cerebroprotection. However, little information is available about the link between them. This study aimed
Huanjun Pan et al.
Journal of cardiovascular pharmacology, 58(5), 535-542 (2011-07-29)
Salvianolic acid A (Sal A), the water-soluble component from the root of the Salvia miltiorrhiza plant, possesses antioxidant, antiproliferative, and antiplatelet properties. However, whether it plays a role in the protection against ischemia-reperfusion (I/R) injury in rat hearts has yet
Ying Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(4), 434-438 (2011-05-24)
To study the chemical changes of salvianolic acid B and lithospermic acid of Salvia miltiorrhiza under the conditions of high temperature and high pressure and explore the reaction mechanism. S. miltiorrhiza extracts, salvianolic acid B and lithospermic acid were put
Kwang-Seok Oh et al.
International immunopharmacology, 11(11), 1901-1906 (2011-08-16)
Salvianolic acid A, an active compound present in Salvia miltiorrhiza, is a phenolic carboxylic acid derivative, ((2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl) ethenyl]-3,4-dihydroxyphenyl] prop-2-enoyl]oxypropanoic acid). The present study was performed to investigate the underlying mechanisms of anti-inflammatory effects with salvianolic acid A, specially focused on
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