SMB00579

Tacalcitol

≥99% (HPLC)

• Sinónimos: (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol, 1α,24R-dihydroxycholecalciferol, 1α,24R-dihydroxyvitamin D₃
• Fórmula empírica (notación de Hill): C₂₇H₄₄O₃
• Número de CAS: 57333-96-7
• Peso molecular: 416.64
• Número MDL: MFCD00866623
• Código UNSPSC: 12352205
• ID de la sustancia en PubChem: 329825068
• NACRES: NA.79

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Análisis: ≥99% (HPLC)
• formulario: powder
• técnicas: HPLC: suitable
• color: white to off-white
• temp. de almacenamiento: −20°C
• cadena SMILES: C[C@]1(CCC/2)[C@](CC[C@]1([H])[C@H](C)CC[C@@H](O)C(C)C)([H])C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C
• InChI: 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
• Clave InChI: BJYLYJCXYAMOFT-RSFVBTMBSA-N

Descripción

Descripción general

Tacalcitol is a synthetic vitamin D₃ analog. It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3.

Acciones bioquímicas o fisiológicas

Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin. Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis. Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P301 + P330 + P331 + P310
• Clasificaciones de peligro: Acute Tox. 1 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable