SAB5701760

Anti-Phospho-Lck-Y505 antibody produced in rabbit

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: liquid
• reactividad de especies: mouse, rat, human
• concentración: 3.79 mg/mL
• técnicas: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:1000
• Nº de acceso UniProt: P06239
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: phosphorylation (pTyr505)
• Información sobre el gen: human ... LCK(3932)

Descripción

Descripción general

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described.

Inmunógeno

A synthetic phosphorylated peptide around Y505 of human Lck (NP_001036236.1).

Forma física

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable